I. How can NMN give you a good night's sleep?

This has to do with the biological clock. The biological clock is a virtual "clock", which is actually the internal rhythmicity of an organism's life activities. The body's biochemistry, physiology, metabolism, immunity, psychology and behaviour are all regulated by the biological clock, and disruption of the biological clock and its rhythms can lead to health problems.

The biological clock is so important, but also very fragile. Factors such as work and rest, diet, age, and even indoor light can interfere with the balance of the biological clock. The reason why modern people develop so many sleep problems is largely related to irregular work and rest habits such as staying up late. If you have long-term sleep disorders, poor sleep quality and other problems, it means that the rhythm of the biological clock is already very serious.

Before NMN came into the public eye, many people would take melatonin to improve their sleep. Melatonin is a hormone that the body produces on its own, less during the day and more at night, thus helping to induce and maintain sleep. However, it is only helpful for people who do not produce enough melatonin at night (e.g. some older people). If the body does not lack melatonin, blind supplementation is not only ineffective, but may also produce side effects such as dizziness and nausea.

The principle of NMN to improve sleep is different, after supplementing NMN can enhance the body's NAD+ level, and NAD+ and the biological clock also have a great relationship, the interaction between NAD+ and the biological clock is manifested in the following way: the metabolism of NAD+ is regulated by the biological clock, which in turn also has an impact on the biological clock.

  • When the biological clock is disturbed by various factors, it affects NAD+ synthesis
  • And when NAD+ is disturbed, it also affects the biological clock.

For people who do not get enough sleep and have irregular work and rest, boosting the level of NAD+ in the body can help regulate the biological clock and bring it back to its normal circadian rhythm.

For the elderly who sleep regularly but with reduced sleep quality, the accelerated loss of NAD+ due to ageing will reduce the gene expression of the biological clock and make it less adaptable. This is when the inherent cycle of the biological clock can be adjusted through NMN, making it more adaptable. This is the reason why many seniors who take NMN have improved sleep quality and are more likely to sleep through the night.


II. To improve sleep, it's important to know when to take NMN.

In the practical application of NMN, there are some people feedback that after taking it, they can't sleep well instead or they are always sleepy during the day, what's going on? This may be due to the following situations:

1. Taking NMN at night.

NMN elevates the level of NAD+ in the body, which in turn increases the level of ATP, the mitochondrial energy molecule, which will make the energy high. If you take NMN at night, the excitement level tends to become higher, which will easily lead to difficulty in falling asleep. This is especially true for people who are already more excited at night.

Therefore, for most people, taking NMN at night is not recommended.Generally, it is recommended to take NMN in the morning, midday, or afternoon, and since everyone's biological clock is different, it's important to find a time that works for you.


2. Long-term sleep "debt".

Some friends have long-term late night, sleep deprivation, after taking NMN is likely to appear always sleepy. This is due to long-term sleep debt, so that the nerve cells are in a constant state of stress, resulting in nerve cell DNA damage, nerve sensitivity decreased.

After taking NMN, with the increase of NAD+ level, the cells start to enter the benign repair mode, and an important part of cell self-repair is the need for good sleep, the body will regulate sleep, using more and more high-quality sleep to complete self-repair. At this time, there will be a phase of "sleepiness", feeling always sleepy, never wake up. It is recommended that you combine this with adequate nutrition and a reasonable work schedule to accelerate cellular self-repair. Depending on your situation, it can take as little as one week or as much as one month to relieve the phenomenon of periodic drowsiness.


3. Disorders of the biological clock.

There are some people whose biological clock rhythm is already in a very disturbed state. For example, long-term irregular work and rest, sometimes sleep at 10 p.m., sometimes 2:00 or 3:00 a.m. to go to sleep; or long-term are sleeping during the day, the middle of the night is very energetic; or often wake up in the middle of the night can not sleep. In this case, the adjustment will take longer than the average person, and it may take 1 to 2 months to gradually adjust from the disordered state.

It is recommended to adjust the time of taking NMN according to your own work and rest time. For example, if you often go to bed at 2:00 or 3:00 am and get up at 10:00 am, you can consider starting at 10:00 am in the morning, 14:00 pm in the afternoon, and 20:00 pm in the evening, and accordingly find a suitable time for you to take NMN. In addition, you can also increase the dosage of NMN according to your situation.