Cardiovascular disease is a major cause of death worldwide, claiming an estimated 17.9 million lives each year.So what should we do to prevent cardiovascular problems in response to this situation?

Studies have shown that NMN can prevent cardiovascular disease.

The pathophysiology of cardiovascular diseases is complex and mainly involves metabolic disorders, oxidative stress and inflammation. And NAD+, as a common substrate for a variety of key enzymes, is involved in various biological processes such as cellular substance metabolism, energy synthesis and cellular DNA repair.

Recently, more and more scientific research has proven that replenishing and stabilising NAD+ levels in the body by taking NMN is now one of the ideal ways to treat or even prevent cardiovascular diseases.

1.NMN improves vascular smooth muscle senescence.

Vascular ageing is one of the direct causes of ageing in the body, and how to keep blood vessels young has become a focus of research in the field of ageing inhibition.

A study authored by a team of researchers shows that decreased intracellular levels of NAD+ (nicotinamide adenine dinucleotide) due to CD38, one of the NAD+ metabolic pathways, is an important cause of age-related cardiovascular disease.

In contrast, supplementation with NMN (β-nicotinamide mononucleotide) or inhibition of CD38 both increased NAD+ levels and delayed vascular smooth muscle cell senescence and pathological structural changes in mice.


It was found that CD38 not only catabolizes NAD+, but also consumes precursors such as NMN, which are necessary for the synthesis of NAD+. Compared to normal mice, CD38-deficient mice had an almost 50% increase in intracellular NAD+ levels in the aorta.

To explore whether NAD+ supplementation could rescue vascular smooth muscle cell senescence, researchers administered NMN (300mg/kg) orally to normal mice.

The results showed an increase in NAD+ levels in the mice and an improvement in angiotensin II-induced hypertension symptoms. In addition, the intima-media thickness, intima-to-lumen ratio and collagen deposition of the vessels were reduced by 26%, 27% and 30% respectively.

2.NMN effectively inhibits cardiac dysfunction caused by Echs1 deficiency.

As research continued, in April 2022, a team of researchers from the Children's Hospital of Fudan University and the School of Life Sciences published their findings in JACC (Journal of the American College of Cardiology): NMN effectively inhibits cardiac dysfunction caused by Echs1 deficiency. Of course this is not the first time that NMN has unlocked a function to protect the heart.

Echs1 (short-chain enzyme A hydratase 1) is a key enzyme in the oxidation of fatty acids (FA) and branched-chain amino acids (BCAAs) and is closely associated with the development of cardiomyopathy.

In contrast, NMN is able to mediate histone acetylation and target the prevention of ECHS1-deficient cardiomyopathy, making NMN supplementation a potential cardiomyopathy prevention tool. The article was published in the medical journal Theranostics, a region 1 journal.

3.The promise of NMN in cardiovascular disease prevention.

Indeed, cardiovascular disease has been a hot topic of NMN research in recent years.

Since the pathogenesis of cardiovascular diseases usually lies in the diastole and contraction of cardiomyocytes. Cardiomyocytes have to keep on diaphrasing and contracting throughout their lives to keep the heart functioning properly, so they have a very high energy requirement and mitochondria are its energy supply assistants.

Therefore, repairing and enhancing mitochondrial function in cardiomyocytes is a very important factor in the prevention and treatment of cardiovascular disease.

The ability of NMN to significantly enhance mitochondrial function is some evidence that NMN has positive effects in the treatment and prevention of cardiovascular disease, and has great potential for future clinical treatment.