Cardiovascular diseases are common in middle-aged and elderly people over 50 years old. As age rises, blood flow in the body slows down, triggering hyperlipidaemia, thickened blood, atherosclerosis and hypertension, causing ischaemic or bleeding in the heart, brain and tissues throughout the body.
And hot and cold weather can easily constrict blood vessels, which are more constricted and can cause unstable blood pressure, thus easily triggering cardiovascular disease.
NMN slows vascular ageing
NMN activates our Sirtuins, also known as silencing regulatory proteins, which are NAD+-dependent class III histone deacetylases in mammals and play a key role in regulating growth, development, ageing and various diseases by regulating the acetylation levels of various proteins in cells.Recent studies have found that Sirtuins are closely related to vascular remodelling disease through a variety of mechanisms.
NMN is rapidly absorbed by the body after oral administration and can penetrate cell membranes, thus synthesizing NAD+ in cells and increasing the level of NAD+ in the body, which in turn can reverse the aging process of blood vessels and act in the prevention and improvement of cardiovascular and cerebrovascular diseases.
NMN for prevention of cerebral infarction
Cerebral infarction is the most common type of cerebrovascular disease, accounting for approximately 70% of all acute cardiovascular and cerebrovascular diseases, and is most common in middle-aged and elderly patients, with a female to male patient ratio of 1:1.
In recent years, researchers have discovered that NMN can prevent brain infarction.2019 Researchers at the Health Sciences Center's Division of Geriatrics in the United States found that NMN enhances vascular endothelial cell diastole and promotes blood circulation.
NMN enters the cell and effectively increases the level of NAD+, which in turn increases the expression of SIRTUINS, thus reducing the attack of free radicals on the mitochondria in the cell and maintaining the function of the mitochondria, enabling them to produce nitric oxide. This is a very important cytodilator, and the release of nitric oxide greatly increases vasodilation, which improves cardiovascular flow and cognitive function.
This theory not only provides theoretical support for the ability of NMN to effectively enhance endothelial cell diastole and improve blood supply to brain tissue, but also provides a new research direction for preventing brain infarction and enhancing cognitive function.
NMN reduces brain haemorrhage injury
Intracerebral hemorrhage (ICH) is a primary brain injury caused by mechanical damage that results in a haematoma. It can sometimes develop into a secondary injury, mainly with subsequent pathophysiological changes, including blood-brain barrier (BBB) disruption, haemoglobin-induced iron overload, neuronal cell death, neuroinflammation and oxidative stress. It often occurs in patients over 50 years of age with a history of hypertension and has a high mortality and disability rate, posing a serious health risk.
It has been found that NMN can protect brain nerves and promote nerve regeneration in blood vessels by activating the NAD+ defence system, and is a potential anti-stroke drug for repairing nerve damage caused by both cerebral haemorrhage and cerebral haemorrhage transformation.
NMN has a protective effect against ischaemic brain injury.
The scientific team further showed that NMN enhanced the expression of cytoprotective proteins, inhibited neuroinflammation and oxidative stress in the brain, and reduced damage after intracerebral haemorrhage.
NMN prevents atherosclerosis
Healthy arteries are elastic, but over time their walls harden, a condition commonly referred to as atherosclerosis.
In May 2019, scientists such as Kiss Tamas of the Department of Geriatrics at the University of Oklahoma Health Sciences Center showed through experimental studies in mouse models that NMN reverses levels of a type of blood vessel called MIRNA, rejuvenates epigenetics and resists atherosclerosis, which simply means that NMN prevents atherosclerosis and prevents the aging of blood vessels.
Through continuous research, scientists have found that NMN reduces the degree of atherosclerosis, improves the elasticity of blood vessel walls, softens the blood vessels of the elderly and prevents cardiovascular diseases.