Sleep is an important physiological function that sustains human life, of which about one third of a person's life is spent in sleep. Poor sleep can lead to disruptions in the body's biological clock and serious problems with internal reactions, which can greatly affect health and longevity.

According to the World Health Organisation, 27% of the world's population has sleep problems, with 20-50% of people aged 65 and over suffering from insomnia. These people often rely on a variety of external sleep aids or bedding to alleviate their insomnia. However, it is not possible to get to the root of the problem.

In a paper published in Cell, it was shown that older people are more likely to suffer from sleep disorders because their biological clocks are more likely to become disturbed as they age, and their circadian regulation is reduced. The reason why older people often wake up in the middle of the night or cannot sleep is that when the biological clock is disrupted, the body organs do not think that it is night time and that it is not time to sleep, but they are still active and secreting chemicals as they do during the day.

It has been proven through a series of studies that NAD+ is a key substance for the healthy functioning of the biological clock, and that proper supplementation of NAD+ can rejuvenate the ageing biological clock. In today's anti-ageing and biology community, NMN is generally considered to be the most scientific and effective way to supplement NAD+.

How does NMN allow you to get a good night's sleep?

In fact, it has to do with the biological clock. The biological clock is a virtual 'clock', which is actually the intrinsic rhythm of an organism's life activities. The body's biochemistry, physiology, metabolism, immunity, psychology and behaviour are all regulated by the biological clock, and disruptions in the biological clock and biorhythms can lead to health problems. The biological clock is so important, but also so fragile that factors such as work, diet, age and even indoor light can interfere with the balance of the biological clock. A large part of the reason why so many modern people have sleep problems is related to irregular work habits such as staying up late. If you have chronic problems such as sleep disorders and poor sleep quality, it means that the rhythm of your biological clock is already seriously out of balance.

For people who are sleep deprived and have an irregular routine, boosting NAD+ levels in the body can help regulate the biological clock and restore it to its normal circadian rhythm. For older people who sleep regularly but with reduced sleep quality, the accelerated loss of NAD+ due to ageing can reduce the gene expression of the biological clock, making it less adaptable. This is when the inherent cycle of the biological clock can be adjusted with NMN, making it more adaptive. This is the reason why many older people taking NMN have improved sleep quality and are more likely to sleep through the night.

When to take NMN to improve sleep?

In the practical application of NMN, there are some consumers' feedback that they have trouble sleeping or are sleepy during the day after taking it. It may be that the following situations occur:

1. NMN was taken at night.

Taking NMN at night raises the level of NAD+ in the body, which in turn increases the level of the mitochondrial energy molecule ATP, which can lead to high energy levels. If you take NMN at night, your excitement level tends to become higher, which can easily lead to difficulties in falling asleep.

This will be especially noticeable in people who are already more aroused at night. Therefore, for most people, it is not recommended to take NMN at night, and in general, it is recommended to take it in the morning and at noon. Since everyone's biological clock is different, it is important to find a time that suits you.

2. Lack of sleep due to chronic irregularity rest.

Some people who are chronically stay up late and sleep deprived are likely to have trouble sleeping after taking NMN. This is due to chronic sleep deprivation, which puts nerve cells in a constant state of stress, resulting in DNA damage to nerve cells and reduced nerve sensitivity.

After taking NMN, with the increase of NAD+ level, the cells start to enter into a benign repair mode, and an important part of cellular repair is the need for good sleep. This is when a phase of 'sleepiness' occurs, where you feel sleepy all the time and can't get enough sleep.

It is recommended to combine with adequate nutrition and a reasonable rest and relaxation schedule to speed up the self-repair of cells. Depending on yourselves situation, the stage drowsiness will be relieved in as little as a week or as long as a month.

3. Disruption of the biological clock and inappropriate timing of administration.

There are some people whose biological clock rhythm is already very disturbed. For example, if you have been sleeping irregularly for a long time, sometimes at 10pm and sometimes at 2am or 3am; or if you have been sleeping during the day and are very alert in the middle of the night; or if you often wake up in the middle of the night and cannot sleep. In these cases, it can take longer than normal to adjust, perhaps 1 to 2 months, to gradually recover from the disorder.

It is advisable to adjust the time of taking NMN according to your daily routine. For example, if you often go to bed at 2:00 or 3:00 am and get up at 10:00 am, you can consider that you start at 10:00 am in the morning, 14:00 pm at noon and 20:00 pm at night, to find the right time for you. In addition, you can also increase the amount of NMN you take according to your situation.

A few things to look out for when it comes to getting a good night's sleep scientifically.

In addition to using NMN to help regulate sleep, there are a number of factors in our daily habits that are particularly likely to affect sleep and should not be ignored.

1. Sleep with the light on.

Sleeping with the lights on can disrupt the biological clock. A large study of over 40,000 female, published in a JAMA sub-journal, shows that sleeping with the lights on at night not only has a direct impact on sleep disruption and circadian rhythms, but may also lead to obesity in women.

2. Play with your mobile phone before bedtime.

Many people have the habit of playing with their phones before bed, and a paper published in the journal Frontiers in Psychiatry, which surveyed over 1,000 students, found a very clear relationship between late-night phone use addiction and poor sleep.

3. Bedtime exercise

Moderate exercise helps to get a good night's sleep, but if you exercise 2 hours before bedtime, it can have the opposite effect. This is due to the fact that exercise raises the excitement level and if you exercise too late, your mind is in a state of euphoria, which can also cause difficulties in falling asleep.